In a large bowl, combine the ground beef with the salt, pepper, garlic powder, and smoked paprika. Gently mix until just combined, then form into four equal-sized patties.
Preheat your smoker or grill to 225-250°F (110-120°C), and prepare your smoking wood for the desired smoke flavor.
Place the beef patties on the smoker grate and smoke for 45-60 minutes, or until the internal temperature reaches 130-140°F (55-60°C) for medium-rare.
During the last 10 minutes of smoking, brush the patties with BBQ sauce to allow the flavors to meld together.
Cook the bacon slices in a skillet or on the grill until crispy.
Halve the hamburger buns and toast them on the grill or in a skillet until lightly golden.
Place a slice of cheddar cheese on top of each smoked patty and allow it to melt.
Assemble the burgers: on the bottom bun, place a lettuce leaf, followed by the cheesy patty, crispy bacon, tomato slices, and red onion.
Drizzle with a little extra BBQ sauce and Dijon mustard, then top with the other half of the bun.
Serve hot, accompanied by fries or coleslaw.
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