Prepare the brisket: trim excess fat, then generously rub with the barbecue rub, salt, and pepper. Ensure the entire surface is evenly coated.
Set your smoker to 225°F (110°C) and add the smoking wood (e.g., hickory or oak). Allow the smoker to preheat until it reaches the desired temperature.
Place the brisket in the smoker, fat-side up. Smoke for 6-8 hours, monitoring the temperature periodically and adding more wood as needed.
When the internal temperature of the brisket reaches 195-205°F (90-95°C), remove it from the smoker and wrap tightly in aluminum foil. Let it rest for 1 hour to allow the juices to redistribute.
Before serving, slice the brisket into thin slices against the grain and serve with barbecue sauce. Complement with sides like baked beans, cornbread, or a fresh salad.
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