In a large bowl, combine the flour, powdered sugar, and a pinch of salt. Add the cold, cubed butter and rub it into the flour mixture until it resembles coarse crumbs.
Add the egg yolks and mix until a smooth dough forms. Wrap in plastic wrap and chill in the refrigerator for 30 minutes.
Preheat the oven to 350°F (180°C). Roll out the dough and line a pie dish with it. Prick the bottom with a fork. Blind-bake for 15 minutes.
For the filling, scrape the seeds from the vanilla bean into a saucepan with the milk. Heat until warm, but do not boil.
In a bowl, whisk together the granulated sugar and cornstarch. Gradually pour in the warm milk, whisking constantly to prevent lumps.
Pour the mixture back into the saucepan and cook over low heat, stirring constantly, until it thickens. Be careful not to let it boil!
Pour the vanilla cream into the pre-baked pie crust and smooth the top.
Bake for an additional 20 minutes at 350°F (180°C), or until the filling is slightly set.
Let the pie cool completely. Dust the top with powdered sugar, slice, and serve.
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